Raitakari Maria, Ilvonen Thomas, Ahotupa Markku, Lehtimäki Terho, Harmoinen Aimo, Suominen Pauli, Elo Juhani, Hartiala Jaakko, Raitakari Olli T
Department of Clinical Chemistry, University of Turku, Finland.
Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):124-8. doi: 10.1161/01.ATV.0000109749.11042.7c. Epub 2003 Dec 1.
Obesity is associated with endothelial dysfunction that may contribute to the development of atherosclerosis. We studied whether weight reduction improves endothelial function in overweight individuals.
Flow-mediated endothelium-dependent vasodilation of the brachial artery was measured in 67 adults (age: 46+/-7 years, body mass index: 35.2+/-5.4 kg/m2) before and after a 6-week weight reduction program induced by very-low-calorie diet (daily energy: 580 kcal/2.3 MJ). Caloric restriction reduced body weight from 101+/-18 to 90+/-17 kg. Flow-mediated vasodilation increased from 5.5%+/-3.7 to 8.8%+/-3.7% (P<0.0001). Nitrate-mediated vasodilation was not significantly affected. The improvement in flow-mediated dilation was associated with the reduction in plasma glucose concentration (P=0.0003). This relationship was independent of changes in weight, serum lipids, oxidized LDL, C-reactive protein, adiponectin, blood pressure, and insulin.
Weight reduction with very-low-calorie diet improves flow-mediated vasodilation in obese individuals. This improvement is related to the reduction in plasma glucose concentration. These observations suggest that changes in glucose metabolism may determine endothelial vasodilatory function in obesity.
肥胖与内皮功能障碍相关，而内皮功能障碍可能促进动脉粥样硬化的发展。我们研究了体重减轻是否能改善超重个体的内皮功能。
对67名成年人（年龄：46±7岁，体重指数：35.2±5.4kg/m²）在采用极低热量饮食（每日能量：580千卡/2.3兆焦）进行为期6周的减重计划前后，测量肱动脉血流介导的内皮依赖性血管舒张功能。热量限制使体重从101±18千克降至90±17千克。血流介导的血管舒张功能从5.5%±3.7%增加到8.8%±3.7%（P<0.0001）。硝酸盐介导的血管舒张功能未受到显著影响。血流介导的血管舒张功能的改善与血浆葡萄糖浓度的降低相关（P=0.0003）。这种关系独立于体重、血脂、氧化型低密度脂蛋白、C反应蛋白、脂联素、血压和胰岛素的变化。
采用极低热量饮食减重可改善肥胖个体的血流介导的血管舒张功能。这种改善与血浆葡萄糖浓度的降低有关。这些观察结果表明，糖代谢的变化可能决定肥胖状态下的内皮血管舒张功能。
