Tzeng Jann-Inn, Chu Koung-Shing, Ho Shung-Tai, Cheng Kuang-I, Liu Kuo-Sheng, Wang Jhi-Joung
Departments of Medical Research and Anesthesiology, Chi-Mei Medical Center, Tainan, Taiwan.
Can J Anaesth. 2003 Dec;50(10):1023-6. doi: 10.1007/BF03018366.
To evaluate the prophylactic effect of ondansetron on nausea and vomiting following epidural morphine for postoperative pain control.
Seventy women (n = 35 in each group) undergoing abdominal total hysterectomy under epidural anesthesia were enrolled in this randomized, double-blinded, and placebo-controlled study. At the end of surgery, all patients received epidural morphine 3 mg for postoperative pain relief. Before morphine injection, the ondansetron group received iv ondansetron 4 mg, whereas the placebo group received iv saline.
Patients in the ondansetron group reported a lower frequency of total postoperative nausea and vomiting (22%) and lower frequency of rescue antiemetic request (12%) than those in the placebo group (52% and 39%, respectively; P < 0.05). In addition, ondansetron was associated with a reduced incidence of pruritus following epidural morphine (28% vs 58%; P < 0.05).
We conclude that iv ondansetron 4 mg is effective in the prevention of nausea, vomiting, and pruritus following epidural morphine for postoperative pain control.
评估昂丹司琼对硬膜外吗啡用于术后疼痛控制后恶心和呕吐的预防作用。
本随机、双盲、安慰剂对照研究纳入了70例行硬膜外麻醉下腹部全子宫切除术的女性患者（每组n = 35）。手术结束时，所有患者均接受3 mg硬膜外吗啡用于术后镇痛。在注射吗啡前，昂丹司琼组静脉注射4 mg昂丹司琼，而安慰剂组静脉注射生理盐水。
与安慰剂组相比，昂丹司琼组患者术后恶心和呕吐的总发生率（22%）及补救性使用止吐药的频率（12%）更低（安慰剂组分别为52%和39%；P < 0.05）。此外，昂丹司琼与硬膜外吗啡后瘙痒发生率降低相关（28%对58%；P < 0.05）。
我们得出结论，静脉注射4 mg昂丹司琼可有效预防硬膜外吗啡用于术后疼痛控制后出现的恶心、呕吐和瘙痒。
