Department of Anesthesiology, Children’s National Medical Center, George Washington University Washington, DC, USA.
Ther Clin Risk Manag. 2007 Jun;3(2):333-9. doi: 10.2147/tcrm.2007.3.2.333.
The introduction of 5-HT(3) receptor antagonist has revolutionized the prevention and treatment of nausea and vomiting in preschool aged children. These distressing symptoms, arising from multiple etiologies such as anesthesia, chemotherapy, and viral infection, are a major concern of patients and their families. Clinical research has demonstrated the antiemetic effectiveness of ondansetron in children. Although most of these studies focus primarily on preventing vomiting across the pediatric age group, they provide strong evidence for the use of ondansetron in preschool age children. For children at high risk, pediatric practice guidelines recommend ondansetron in conjunction with other antiemetics to achieve complete control of symptoms.
5-HT(3) 受体拮抗剂的问世，彻底改变了儿童期患者恶心和呕吐的预防和治疗。这些令人痛苦的症状，源于多种病因，如麻醉、化疗和病毒感染，是患者及其家属关注的主要问题。临床研究已经证实了昂丹司琼在儿童中的止吐作用。尽管这些研究大多主要集中在预防儿科年龄组的呕吐，但它们为昂丹司琼在学龄前儿童中的应用提供了强有力的证据。对于高风险儿童，儿科临床实践指南建议昂丹司琼与其他止吐药联合使用，以完全控制症状。
