Kalla A A, Brown G M, Meyers O L
Department of Medicine, Groote Schuur Hospital, University of Cape Town.
S Afr Med J. 1992 Dec;82(6):411-4.
Sixty-five patients with rheumatoid arthritis (RA) (mean age 37.2 years) were compared with 71 controls (mean age 33.8 years). Anthropometric measurements included body diameters and skin-fold thickness at multiple sites, while biochemical markers of nutritional status included serum albumin, thyroxine-binding pre-albumin and retinol-binding globulin levels. None of the RA subjects was outside the range that extended 2 standard deviations above and below the normal control values for lean body mass. Discriminant analysis showed that corticosteroid therapy did not significantly influence skinfold thickness in RA. A combination of bi-acromial and bi-ankle diameters had a sensitivity of 70% and a specificity of 72% in differentiating the RA group, in whom disease activity had a greater effect on body diameters than corticosteroid therapy did. Differences related to functional impairment were a manifestation of disease activity rather than a direct effect on skinfold thickness or body diameters. According to anthropometric measurements in ambulant patients, RA does not result in malnutrition in young individuals.
将65例类风湿性关节炎（RA）患者（平均年龄37.2岁）与71名对照者（平均年龄33.8岁）进行比较。人体测量指标包括多个部位的身体直径和皮肤褶厚度，而营养状况的生化指标包括血清白蛋白、甲状腺素结合前白蛋白和视黄醇结合球蛋白水平。没有一名RA患者超出正常对照者瘦体重值上下2个标准差的范围。判别分析表明，皮质类固醇疗法对RA患者的皮肤褶厚度没有显著影响。双肩峰直径和双踝直径相结合在区分RA组时敏感性为70%，特异性为72%，在RA组中疾病活动对身体直径的影响大于皮质类固醇疗法。与功能损害相关的差异是疾病活动的表现，而不是对皮肤褶厚度或身体直径的直接影响。根据对能走动患者的人体测量，RA不会导致年轻个体营养不良。
