Helliwell M, Coombes E J, Moody B J, Batstone G F, Robertson J C
Ann Rheum Dis. 1984 Jun;43(3):386-90. doi: 10.1136/ard.43.3.386.
A nutritional assessment of 50 patients with rheumatoid arthritis (RA) showed evidence of malnutrition in 13 (26%), while all 50 control subjects had normal nutritional status. Of the anthropometric measurements the body-mass index and triceps skinfold thickness values in men and women were significantly reduced in RA patients compared with controls. Upper arm muscle circumference was significantly less in male but not female rheumatoid patients. In addition all six biochemical determinants of nutrition assayed-serum albumin, transferrin, retinol-binding protein, thyroxine-binding prealbumin, zinc, and folic acid-were significantly lower in the RA group of patients. Malnourished patients had more active disease than the remaining RA patients, with significantly higher ESR, C-reactive protein, and alpha 1 antichymotrypsin measurements. Significant inverse correlations were found between some biochemical measurements of nutrition and indices of disease activity. Our results suggest that in RA the severity of disease adversely affects the nutritional status.
对50例类风湿性关节炎（RA）患者进行的营养评估显示，13例（26%）存在营养不良迹象，而所有50例对照受试者的营养状况均正常。在人体测量指标中，与对照组相比，RA患者的男性和女性体重指数及肱三头肌皮褶厚度值均显著降低。男性类风湿患者的上臂肌肉周长显著小于女性。此外，所检测的所有六项营养生化指标——血清白蛋白、转铁蛋白、视黄醇结合蛋白、甲状腺素结合前白蛋白、锌和叶酸——在RA患者组中均显著较低。营养不良患者的疾病活动度比其余RA患者更高，血沉、C反应蛋白和α1抗糜蛋白酶的测量值显著更高。在一些营养生化指标与疾病活动指数之间发现了显著的负相关。我们的结果表明，在RA中，疾病的严重程度会对营养状况产生不利影响。
