Pederson Thoru
Department of Biochemistry and Molecular Pharmacology and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Mol Biol Cell. 2004 Feb;15(2):407-10. doi: 10.1091/mbc.e03-10-0726. Epub 2003 Dec 2.
The discoveries of RNA interference and RNA-mediated posttranscriptional gene silencing have opened an unanticipated new window on the regulation of gene expression as well as a facile and highly effective tool for knocking down gene expression in many organisms and cells. In addition, RNA interference and RNA silencing may conceivably be exploited for human therapeutics sometime in the future, possibly bringing greater clinical impact than have the so far disappointing antisense endeavors. This essay summarizes recent developments and offers some personalized perspectives, with emphasis on what we do not yet know.
RNA干扰和RNA介导的转录后基因沉默的发现，为基因表达调控打开了一扇意想不到的新窗口，同时也为在许多生物体和细胞中敲低基因表达提供了一种简便且高效的工具。此外，RNA干扰和RNA沉默在未来某个时候有望被用于人类治疗，可能会带来比迄今为止令人失望的反义技术更大的临床影响。本文总结了近期的进展并提供了一些个人观点，重点在于我们尚不了解的方面。
