Grandori Carla, Robinson Kristin L, Galloway Denise A, Swisshelm Karen
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Cell Cycle. 2004 Jan;3(1):22-5.
We have recently reported a connection between the expression of the Werner syndrome gene (WRN), whose loss of function has been implicated in a human progeroid syndrome (WS), and the Myc oncoprotein. Myc overexpression directly elevates trancription of the WRN gene, whose presence is required to avoid senescence during Myc proliferative stimuli. Here we discuss several hypotheses to explain why WRN might be required to support oncogenic proliferation in light of the known function of WRNprotein and Myc in genomic instability and transcriptional modulation. In addition, we address the apparent paradox of why patients with WS, lacking WRN function, have increased incidence of certain cancers.
我们最近报道了沃纳综合征基因（WRN）的表达与Myc癌蛋白之间的联系，该基因功能缺失与一种人类早老综合征（WS）有关。Myc的过表达直接提高了WRN基因的转录水平，在Myc增殖刺激过程中，WRN基因的存在是避免细胞衰老所必需的。鉴于WRN蛋白和Myc在基因组不稳定和转录调控方面的已知功能，我们在此讨论几种假设，以解释为什么可能需要WRN来支持致癌增殖。此外，我们还探讨了一个明显的矛盾，即缺乏WRN功能的WS患者为何某些癌症的发病率会增加。
