Yilmaz F, Gül T, Uzunlar A K
Department of Pathology, Obstetrics and Gynecology, Medical Faculty of Dicle University, Diyarbakir, Turkey.
Eur J Gynaecol Oncol. 2003;24(6):569-73.
In this study, some clinicopathologic characteristics and the outcome of patients with malignant ovarian germ cell tumors (MOGCT) were evaluated.
The clinical charts and pathologic reports of 32 patients with MOGCT treated at the Department of Obstetrics and Gynecology, and diagnosed at the Department of Pathology, Medical Faculty of Dicle University, Turkey from 1983 to 1999 were reviewed.
Thirteen patients (40.6%) had dysgerminoma, nine (28.1%) had immature teratoma (four grade 1, three grade 2, and two grade 3), eight (25%) had endodermal sinus tumor, and two (6.3%) patients had mixed germ cell tumors. Site of involvement was unilateral in 30 (19 on the right and 11 on the left) and bilateral in two. All patients underwent primary surgery and 26 patients combination chemotherapy. There seemed to be a relationship between pathologic findings and clinical outcome, and MOGCT histologic types may affect the prognosis.
Dysgerminoma had a better prognosis than the nondysgerminomatous group (p < 0.05). This study provides additional data in confirmation of previous reports that management of MOGCT with fertility preservation is safe.
本研究评估了恶性卵巢生殖细胞肿瘤（MOGCT）患者的一些临床病理特征及预后。
回顾了1983年至1999年在土耳其迪克莱大学医学院病理学系诊断、在妇产科接受治疗的32例MOGCT患者的临床病历和病理报告。
13例（40.6%）为无性细胞瘤，9例（28.1%）为未成熟畸胎瘤（4例1级，3例2级，2例3级），8例（25%）为内胚窦瘤，2例（6.3%）为混合性生殖细胞肿瘤。受累部位单侧30例（右侧19例，左侧11例），双侧2例。所有患者均接受了初次手术，26例患者接受了联合化疗。病理结果与临床结局之间似乎存在关联，MOGCT的组织学类型可能影响预后。
无性细胞瘤的预后优于非无性细胞瘤组（p < 0.05）。本研究提供了更多数据，证实了之前关于保留生育功能治疗MOGCT是安全的报道。
