Ayhan A, Tuncer Z S, Yanik F, Bükülmez O, Yanik A, Küçükali T
Department of Obstetrics and Gynecology, Hacettepe University School of Medicine, Ankara, Turkey.
Acta Obstet Gynecol Scand. 1995 May;74(5):384-90. doi: 10.3109/00016349509024434.
To determine the most important prognostic factors in patients with malignant germ cell tumors of the ovary.
Age, histologic type, tumor size, stage, treatment mode, type of surgery of 67 patients with malignant germ cell tumors managed consecutively were evaluated retrospectively using multivariate analysis.
The overall survival rate was 60.6%. This figure was 78.5% for dysgerminoma, 53.3% for immature teratoma, 12.0% for endodermal sinus tumor, 33.3% for mixed germ cell tumor and 100.0% for others. The patients with endodermal sinus tumor had significantly poorer survival than other groups. Among the factors analyzed for survival histologic type was found to be the most significant predictor for survival.
Finding of histologic type as the strongest independent risk factor may be evaluated in correlation with the literature that these tumors have historically been investigated as dysgerminomatous and nondysgerminomatous tumors. Furthermore, endodermal sinus tumors had long been known for poor survival. Based on this data, despite advent of staging and effective chemotherapy, prognosis still is basically related to histologic type and histology of tumor should be taken into account while comparing results.
确定卵巢恶性生殖细胞肿瘤患者最重要的预后因素。
对连续收治的67例恶性生殖细胞肿瘤患者的年龄、组织学类型、肿瘤大小、分期、治疗方式、手术类型进行回顾性评估，并采用多因素分析。
总生存率为60.6%。其中，无性细胞瘤为78.5%，未成熟畸胎瘤为53.3%，内胚窦瘤为12.0%，混合性生殖细胞肿瘤为33.3%，其他为100.0%。内胚窦瘤患者的生存率明显低于其他组。在分析的生存因素中，组织学类型是最显著的生存预测因素。
组织学类型是最强的独立危险因素，这一发现可结合以往将这些肿瘤分为无性细胞瘤和非无性细胞瘤进行研究的文献进行评估。此外，内胚窦瘤长期以来一直被认为预后较差。基于这些数据，尽管有了分期和有效的化疗，预后仍然基本上与组织学类型相关，在比较结果时应考虑肿瘤的组织学。
