Keith Samuel J, Kane John M
Department of Psychiatry, University of New Mexico, Albuquerque 87131-1161, USA.
J Clin Psychiatry. 2003 Nov;64(11):1308-15. doi: 10.4088/jcp.v64n1105.
The primary objective of this review is to evaluate the strategies used to improve patient compliance with antipsychotic medication in the treatment of schizophrenia.
An electronic literature search of relevant studies using MEDLINE and the Cochrane Library (January 1974-December 2002) was performed using the search terms adherence, antipsychotic, atypical, compliance, conventional, and schizophrenia.
English-language and non-English-language articles, references from bibliographies of reviews, original research articles, and other articles of interest were reviewed.
Data quality was determined by publication in the peer-reviewed literature and the most important information was identified.
Atypical antipsychotics are associated with an improved side-effect profile and reduced risk of relapse compared with the older agents. Additional benefit may be provided by long-acting injectable formulations as they provide the confidence of continuous medication coverage.
Successful treatment of patients with schizophrenia requires acknowledgment that partial compliance will present a major barrier to achieving maximum outcomes. Ideally, all patients suspected of partial compliance should be considered suitable for treatment with a long-acting injectable atypical antipsychotic.
本综述的主要目的是评估在精神分裂症治疗中用于提高患者对抗精神病药物依从性的策略。
使用MEDLINE和考克兰图书馆（1974年1月至2002年12月）对相关研究进行电子文献检索，检索词为依从性、抗精神病药、非典型、依从、传统和精神分裂症。
对英文和非英文文章、综述参考文献、原创研究文章及其他相关文章进行了综述。
通过同行评审文献中的发表情况确定数据质量，并识别最重要的信息。
与传统药物相比，非典型抗精神病药物具有更好的副作用谱，且复发风险降低。长效注射制剂可能会带来额外益处，因为它们能确保持续的药物覆盖。
精神分裂症患者的成功治疗需要认识到部分依从性将成为实现最佳疗效的主要障碍。理想情况下，所有怀疑有部分依从性的患者都应被视为适合使用长效注射用非典型抗精神病药物进行治疗。
