McCoy Allison N, Crowley Justin C, Haghighian Golnaz, Dean Heather L, Platt Michael L
Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA.
Neuron. 2003 Dec 4;40(5):1031-40. doi: 10.1016/s0896-6273(03)00719-0.
Movement selection depends on the outcome of prior behavior. Posterior cingulate cortex (CGp) is strongly connected with both limbic and oculomotor circuitry, and CGp neurons respond following saccades, suggesting a role in signaling the motivational outcome of gaze shifts. To test this hypothesis, single CGp neurons were studied in monkeys while they shifted gaze to visual targets for liquid rewards that varied in size or were delivered probabilistically. CGp neurons responded following saccades as well as following reward delivery, and these responses were correlated with reward size. CGp neurons also responded following the omission of predicted rewards. The timing of CGp activation and its modulation by reward could provide signals useful for updating representations of expected saccade value.
动作选择取决于先前行为的结果。后扣带回皮质（CGp）与边缘系统和动眼神经回路都有紧密连接，并且CGp神经元在扫视后会做出反应，这表明其在传达注视转移的动机结果方面发挥作用。为了验证这一假设，研究人员在猴子将目光转向视觉目标以获取大小不同或按概率发放的液体奖励时，对单个CGp神经元进行了研究。CGp神经元在扫视后以及奖励发放后都会做出反应，并且这些反应与奖励大小相关。CGp神经元在预期奖励未出现时也会做出反应。CGp激活的时间及其受奖励的调节可为更新预期扫视价值的表征提供有用信号。
