Dietl T, Vogl L, Dirlich G
Max Planck Institute of Psychiatry, Munich, Germany.
Int J Neurosci. 2004 Jan;114(1):131-42. doi: 10.1080/00207450490249437.
Novelty conditions may elicit stress responses. First session effects are systematic changes in physiological parameters, resulting from the interference of physiological processes with novelty stress. Along with endocrinological changes, these stress responses may be accompanied by alterations of sensory and attentional processes. The present study examines the impact of novelty conditions on event-related potential indicators of auditory information processing and on cortisol. Twenty-two healthy subjects participated in a series of experimental sessions. Auditory-evoked potentials were recorded, and the plasma cortisol levels were determined. The first session causes an activation of the hypothalamo-hypopituitary-adrenal axis. The auditory-evoked potentials show an additional slow negative potential component in the novelty condition. This potential component is maximal at fronto-central electrode sites and reaches its peak at about 240 ms after stimulus onset. Similarities with the processing negativity suggest alterations in attention-related auditory information-processing in the novelty condition encountered in the first session.
新奇环境可能引发应激反应。首次实验效应是生理参数的系统性变化，这是由生理过程受到新奇应激干扰所致。除了内分泌变化外，这些应激反应可能还伴有感觉和注意力过程的改变。本研究考察新奇环境对听觉信息处理的事件相关电位指标以及皮质醇的影响。22名健康受试者参与了一系列实验环节。记录听觉诱发电位，并测定血浆皮质醇水平。首次实验会激活下丘脑 - 垂体 - 肾上腺轴。在新奇环境下，听觉诱发电位显示出一个额外的慢负电位成分。该电位成分在额中央电极部位最大，并在刺激开始后约240毫秒达到峰值。与加工负波的相似性表明，在首次实验中遇到的新奇环境下，与注意力相关的听觉信息处理发生了改变。
