Lee J H, Lee H S, Eun H C, Cho K H
Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
J Dermatolog Treat. 2003 Dec;14(4):212-5.
Dandruff is a chronic scalp condition characterized by scaling. The common causative agent is now accepted to be the lipophilic yeast Malassezia furfur. Ketoconazole, a highly effective antifungal agent against M. furfur has been used for the treatment of dandruff.
To determine whether a 1.5% ciclopirox olamine shampoo is as effective as a 2% ketoconazole shampoo for the treatment of mild to moderate dandruff.
A total of 64 patients, with mild to moderate dandruff, participated in the study. The study consisted of three consecutive phases: a 2-week washout period, a 4-week treatment period and a 2-week post-treatment period. Patients were randomized equally to either the 1.5% ciclopirox olamine shampoo or 2% ketoconazole shampoo. An overall dandruff score was calculated using an area of dandruff involvement score and a severity score. Patients evaluated the presence of pruritus and also reported a global evaluation of efficacy.
In all, 57 patients successfully completed all three phases. The overall dandruff score declined progressively throughout the treatment period for both shampoos. A slight increase in pruritus was observed in the ciclopirox olamine treatment group during the post-treatment phase. Regarding global self-assessment of efficacy, both treatment groups were pleased with their scalp condition following treatment.
Ciclopirox olamine shampoo appears to offer an effective, safe and easy to use treatment for mild to moderate dandruff.
头皮屑是一种以脱屑为特征的慢性头皮疾病。目前公认常见的致病因素是亲脂性酵母糠秕马拉色菌。酮康唑是一种对糠秕马拉色菌高效的抗真菌剂，已用于治疗头皮屑。
确定1.5%环吡酮胺洗发水治疗轻至中度头皮屑是否与2%酮康唑洗发水同样有效。
共有64例轻至中度头皮屑患者参与本研究。该研究包括三个连续阶段：2周的洗脱期、4周的治疗期和2周的治疗后期。患者被随机均分为1.5%环吡酮胺洗发水组或2%酮康唑洗发水组。使用头皮屑累及面积评分和严重程度评分计算总体头皮屑评分。患者评估瘙痒的存在情况，并报告对疗效的总体评价。
共有57例患者成功完成了所有三个阶段。在整个治疗期间，两种洗发水的总体头皮屑评分均逐渐下降。在治疗后期，环吡酮胺治疗组观察到瘙痒略有增加。关于疗效的总体自我评估，两个治疗组对治疗后的头皮状况都很满意。
环吡酮胺洗发水似乎为轻至中度头皮屑提供了一种有效、安全且易于使用的治疗方法。
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