Lashev L D, Pashov D A, Marinkov T N
Department of Pharmacology, Faculty of Veterinary Medicine, Stara Zagora, Bulgaria.
Vet Res Commun. 1992;16(4):293-300. doi: 10.1007/BF01839328.
Comparative studies on some selected pharmacokinetic parameters for kanamycin in sheep, goats, rabbits, chickens and pigeons, and for apramycin in sheep, rabbits, chickens and pigeons were carried out after intravenous administration of the two drugs at a dose of 10 mg/kg. The results revealed that a two-compartment open model was most suitable for kanamycin, while for apramycin a one-compartment open model was usually optimal. The log distribution rate constant (alpha) of kanamycin was significantly correlated to the log of the body mass (r = 0.919, n = 5, p < 0.05). Interspecies differences in the apparent volume of distribution (Vda) of kanamycin were small. These differences were larger for apramycin, as were the variations in the area under the serum concentration-time curve (AUC) and in the total body clearance (ClB) of both kanamycin and apramycin, both having almost a threefold difference depending on the species but without any correlation to body mass. The values of the log half-life of kanamycin in the mammals in this study and also those from data in the literature revealed a significant correlation with log body mass between animal species according to the equation: t1/2 beta = 38.47W0.21 (r = 0.7648, n = 10, p < 0.05).
以10mg/kg的剂量对绵羊、山羊、兔子、鸡和鸽子静脉注射卡那霉素，对绵羊、兔子、鸡和鸽子静脉注射阿普拉霉素后，对这两种药物的一些选定药代动力学参数进行了比较研究。结果表明，二室开放模型最适合卡那霉素，而对于阿普拉霉素，一室开放模型通常是最佳的。卡那霉素的对数分布速率常数（α）与体重的对数显著相关（r = 0.919，n = 5，p < 0.05）。卡那霉素的表观分布容积（Vda）的种间差异较小。阿普拉霉素的这些差异较大，卡那霉素和阿普拉霉素的血清浓度-时间曲线下面积（AUC）和总体清除率（ClB）的变化也是如此，两者根据物种不同几乎有三倍的差异，但与体重无任何相关性。本研究中哺乳动物体内卡那霉素的对数半衰期值以及文献数据中的值根据以下方程显示动物物种之间的对数半衰期与对数体重显著相关：t1/2β = 38.47W0.21（r = 0.7648，n = 10，p < 0.05）。
