Ziv G
Am J Vet Res. 1977 Mar;38(3):337-40.
The in vitro susceptibility of Escherichia coli, Salmonella sp, Pasteurella multocida, and Pseudomonas aeruginosa strains isolated from young calves and their environment to kanamycin and its semisynthetic derivative--amikacin, was compared by the tube dilution method. The minimal inhibitory concentration of amikacin was two- to fourfold lower than the minimal inhibitory concentration of kanamycin for the Salmonella group B, Ps aeruginosa and P multocida strains examined, whereas the E coli and Salmonella group D strains were eqaully susceptible to the 2 antibiotics. The concentrations of amikacin and kanamycin in the serum of calves after single intramuscular injections at 10, 25, and 50 mg/kg were determined, and differences between the 2 antibiotics were not observed. Intramuscular dosage schedules were calculated, based on the sensitivity of the different bacterial strains and the duration of effective serum drug concentrations.
采用试管稀释法比较了从幼龄犊牛及其环境中分离出的大肠杆菌、沙门氏菌、多杀性巴氏杆菌和铜绿假单胞菌菌株对卡那霉素及其半合成衍生物阿米卡星的体外敏感性。对于所检测的B组沙门氏菌、铜绿假单胞菌和多杀性巴氏杆菌菌株，阿米卡星的最低抑菌浓度比卡那霉素低两到四倍，而大肠杆菌和D组沙门氏菌菌株对这两种抗生素的敏感性相同。测定了犊牛单次肌肉注射10、25和50mg/kg剂量后血清中阿米卡星和卡那霉素的浓度，未观察到这两种抗生素之间的差异。根据不同细菌菌株的敏感性和有效血清药物浓度的持续时间计算了肌肉注射给药方案。
