未孕和孕鼠子宫、胎膜、胎盘及羊水中的激肽释放酶样活性。

Kallikrein-like activity in nonpregnant and pregnant rat uterus, fetal membranes, placenta and amniotic fluid.

作者信息

Miatello R M, Lama M C, González E S, Nolly H L

机构信息

Laboratory of Experimental Hypertension and Vasoactive Peptides, Argentine Council of Research (CONICET). Mendoza.

出版信息

Agents Actions Suppl. 1992;38 ( Pt 1):106-13. doi: 10.1007/978-3-0348-7321-5_14.

DOI:10.1007/978-3-0348-7321-5_14

PMID:1466259

Abstract

SBTI-resistant kininogenase activity was found in nonpregnant and pregnant rat uterus, placenta, amniotic fluid and fetal membranes. After trypsin treatment the kininogenase activity increased 2-3 fold. Total kininogenase (active plus inactive) was completely blocked by kallikrein antibodies. The physiological role of these kallikrein-like enzymes is unknown. It is speculated that these enzymes play a local role, perhaps in the processing of polypeptide hormones of through the release of kinins in the regulation of uterine blood flow.

摘要

在未孕和孕鼠的子宫、胎盘、羊水和胎膜中发现了抗大豆胰蛋白酶抑制剂（SBTI）的激肽原酶活性。经胰蛋白酶处理后，激肽原酶活性增加了2至3倍。总激肽原酶（活性加非活性）被激肽释放酶抗体完全阻断。这些类激肽释放酶的生理作用尚不清楚。据推测，这些酶可能发挥局部作用，也许是在多肽激素的加工过程中，或者是通过释放激肽来调节子宫血流。