Johnson James R, Gajewski Abby, Lesse Alan J, Russo Thomas A
Mucosal and Vaccine Research Center, VA Medical Center, University of Minnesota, Minneapolis, Minnesota 55417, USA.
J Clin Microbiol. 2003 Dec;41(12):5798-802. doi: 10.1128/JCM.41.12.5798-5802.2003.
Multiple Escherichia coli isolates from four adults with extraintestinal infections underwent molecular phylotyping and virulence profiling. A patient with secondary peritonitis had two low-virulence E. coli strains from phylogenetic groups A and D. In contrast, three patients with invasive extraurinary infections (septic arthritis/pyomyositis, nontraumatic meningitis/hematogenous osteomyelitis, and pneumonia) each had a single high-virulence phylogenetic group B2 strain resembling typical isolates causing urinary infection and/or sepsis, i.e., extraintestinal pathogenic E. coli.
对从4名患有肠外感染的成年人中分离出的多株大肠杆菌进行了分子系统分型和毒力分析。一名继发性腹膜炎患者有两株来自A和D系统发育组的低毒力大肠杆菌菌株。相比之下，三名患有侵袭性泌尿外感染（脓毒性关节炎/脓性肌炎、非创伤性脑膜炎/血源性骨髓炎和肺炎）的患者每人都有一株高毒力的B2系统发育组菌株，类似于引起尿路感染和/或败血症的典型分离株，即肠外致病性大肠杆菌。
