Yurino M, Kimura H
Asahikawa Medical College, Department of Anaesthesia, Hokkaido, Japan.
Anaesthesia. 1992 Nov;47(11):946-9. doi: 10.1111/j.1365-2044.1992.tb03195.x.
This study compares vital capacity rapid inhalational induction of anaesthesia with sevoflurane and isoflurane. Forty-six volunteers undergoing the procedure had one of the two agents: 25 had sevoflurane and 21 isoflurane. Subjects were unpremedicated and breathed approximately 1.7 MAC equivalents of either vapour. There were no significant differences in the patients' monitored cardiovascular, respiratory, and electrocardiographic variables. The mean time for induction of anaesthesia with sevoflurane (120 s) was significantly shorter than with isoflurane (145 s), reflecting its higher blood-gas solubility. There were fewer induction complications in the sevoflurane group. Subjects in the sevoflurane group found the induction of anaesthesia more pleasant and were more willing to undergo it again compared to subjects in the isoflurane group. We conclude that sevoflurane is superior to isoflurane in vital capacity rapid inhalational induction of anaesthesia, particularly in instances where premedication should be avoided.
本研究比较了七氟烷和异氟烷在肺活量快速吸入诱导麻醉中的效果。46名接受该手术的志愿者被随机分配使用两种药物之一：25人使用七氟烷，21人使用异氟烷。受试者未使用术前用药，吸入约1.7倍最低肺泡有效浓度（MAC）的两种药物蒸汽之一。患者监测的心血管、呼吸和心电图变量无显著差异。七氟烷诱导麻醉的平均时间（120秒）明显短于异氟烷（145秒），这反映了七氟烷更高的血气溶解度。七氟烷组的诱导并发症更少。与异氟烷组相比，七氟烷组的受试者认为麻醉诱导更舒适，并且更愿意再次接受。我们得出结论，在肺活量快速吸入诱导麻醉中，七氟烷优于异氟烷，尤其是在应避免术前用药的情况下。
