Mendes Guilherme M, Selmi André L
Veterinary Teaching Hospital, Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Brasília, DF 70910-970, Brazil.
J Am Vet Med Assoc. 2003 Dec 1;223(11):1608-13. doi: 10.2460/javma.2003.223.1608.
To determine the cardiorespiratory effects of an i.v. infusion of propofol alone or in association with fentanyl, alfentanil, or sufentanil in cats and, for each combination, the minimal infusion rate of propofol that would inhibit a response to noxious stimuli.
Randomized crossover study.
6 cats.
Cats were anesthetized 4 times in random order. After i.v. administration of fentanyl, alfentanil, sufentanil, or saline (0.9% NaCl) solution, anesthesia was induced with propofol (7 mg/kg 13.2 mg/lb], i.v.) and maintained for 90 minutes with a continuous infusion of propofol in conjunction with fentanyl (0.1 microg/kg/min [0.045 microg/lb/min]), alfentanil (0.5 microg/kg/min [0.23 microg/lb/min]), sufentanil (0.01 microg/kg/min [0.004 microg/lb/min]), or saline solution (0.08 mL/kg/min [0.036 mL/lb/min]).
Minimal infusion rate of propofol required to prevent a response to a noxious stimulus was higher when cats received saline solution. After 70 minutes, minimal infusion rate of propofol was significantly higher with fentanyl than with sufentanil. Decreases in heart rate, systolic blood pressure, rectal temperature, and respiratory rate were detected with all treatments. Oxygen saturation did not change significantly, but end-tidal partial pressure of carbon dioxide increased with all treatments. There were no significant differences in recovery times or sedation and recovery scores among treatments.
Results suggest that infusion of propofol in combination with fentanyl, alfentanil, or sufentanil results in satisfactory anesthesia in cats.
确定静脉输注异丙酚单独或与芬太尼、阿芬太尼或舒芬太尼联合应用对猫的心肺影响，并针对每种组合确定抑制对有害刺激反应所需的异丙酚最小输注速率。
随机交叉研究。
6只猫。
猫按随机顺序接受4次麻醉。静脉注射芬太尼、阿芬太尼、舒芬太尼或生理盐水（0.9%氯化钠）溶液后，用异丙酚（7mg/kg[13.2mg/lb]，静脉注射）诱导麻醉，并用异丙酚与芬太尼（0.1μg/kg/min[0.045μg/lb/min]）、阿芬太尼（0.5μg/kg/min[0.23μg/lb/min]）、舒芬太尼（0.01μg/kg/min[0.004μg/lb/min]）或生理盐水溶液（0.08mL/kg/min[0.036mL/lb/min]）持续输注维持90分钟。
猫接受生理盐水溶液时，预防对有害刺激反应所需的异丙酚最小输注速率更高。70分钟后，芬太尼组的异丙酚最小输注速率显著高于舒芬太尼组。所有处理均检测到心率、收缩压、直肠温度和呼吸频率下降。血氧饱和度无显著变化，但所有处理的呼气末二氧化碳分压均升高。各处理组的恢复时间、镇静和恢复评分无显著差异。
结果表明，异丙酚与芬太尼、阿芬太尼或舒芬太尼联合输注可使猫获得满意的麻醉效果。
