Martins Ludimilla C T, Guimarães Jéssica B, Ferraz Henrique T, de Oliveira Flávia Augusta, Gomes Leidiane de S, Chafes Clóvis Júnior C, Santos Thalita de C C, Ogliari Kaline, de Moraes Reiner S, Ribeiro Diego, Ramos Dirceu Guilherme de Souza, Rocha Thiago André S de S, Regalin Doughlas
School of Veterinary Medicine and Animal Bioscience, Federal University of Jataí (UFJ), Jataí 75804-068, Brazil.
School of Veterinary Medicine, North Tocantins Federal University (UFNT), Araguaína 77818-530, Brazil.
Vet Sci. 2024 Aug 9;11(8):360. doi: 10.3390/vetsci11080360.
Opioids are administered epidurally (PV) to provide trans- and postoperative analgesia. Twenty healthy female cats aged between 6 and 24 months and weighing between 2 and 3.7 kg, undergoing elective ovariohysterectomy (OVH), were induced with propofol (8 mg/kg), followed by continuous infusion (0.1-0.4 mg/kg/min). Three groups were defined: CG (0.1 mL/kg of iodinated contrast, = 6), G0.1 (0.1 mg/kg of morphine, = 7), and G0.2 (0.2 mg/kg of morphine, = 7) per VP. All received 0.1 mL/kg of iodinated contrast per VP and injection water to obtain a total of 0.3 mL/kg. Heart rate (HR), systolic blood pressure (SBP), temperature, expired CO, oxygen saturation, and number of rescue analgesics were monitored. Postoperatively, a multidimensional scale was used to assess acute pain in cats for 12 h. The mean HR and SBP in the CG were higher at the time of maximum noxious stimulation and required fentanyl in all groups. Postoperatively, 83%, 28%, and 7% of the animals in CG, G0.1, and G0.2, respectively, received rescue analgesia. In cats undergoing OVH, epidural morphine at doses of 0.1 and 0.2 mg/kg did not prevent the need for intraoperative rescue analgesia but reduced the postoperative analgesic needed.
阿片类药物通过硬膜外（PV）给药以提供术中及术后镇痛。二十只年龄在6至24个月之间、体重在2至3.7千克的健康雌性猫，接受择期卵巢子宫切除术（OVH），用丙泊酚（8毫克/千克）诱导麻醉，随后持续输注（0.1 - 0.4毫克/千克/分钟）。定义了三组：CG组（每VP给予0.1毫升/千克碘化造影剂，n = 6），G0.1组（每VP给予0.1毫克/千克吗啡，n = 7），和G0.2组（每VP给予0.2毫克/千克吗啡，n = 7）。所有组每VP均接受0.1毫升/千克碘化造影剂并给予注射用水，以使总量达到0.3毫升/千克。监测心率（HR）、收缩压（SBP）、体温、呼出二氧化碳、血氧饱和度以及急救镇痛药的使用次数。术后，使用多维量表评估猫12小时内的急性疼痛。在最大伤害性刺激时，CG组的平均HR和SBP较高，且所有组均需要芬太尼。术后，CG组、G0.1组和G0.2组分别有83%、28%和7%的动物接受了急救镇痛。在接受OVH的猫中，0.1毫克/千克和0.2毫克/千克剂量的硬膜外吗啡不能预防术中急救镇痛的需要，但减少了术后所需的镇痛药。
