Dropcho Edward J
Department of Neurology, Indiana University Medical Center, CL 291, Indianapolis, IN 46202, USA.
Curr Oncol Rep. 2004 Jan;6(1):26-31. doi: 10.1007/s11912-996-0006-8.
Paraneoplastic disorders can affect any part of the central or peripheral nervous system. Although relatively uncommon, these disorders are a significant cause of severe neurologic disability among cancer patients. Many paraneoplastic disorders are believed to be caused by an autoimmune response directed against shared neural tumor antigens. This article summarizes the clinical features, possible autoimmune pathophysiology, and management issues for patients with paraneoplastic disorders.
副肿瘤性疾病可累及中枢或周围神经系统的任何部位。尽管相对不常见，但这些疾病是癌症患者严重神经功能障碍的重要原因。许多副肿瘤性疾病被认为是由针对共同神经肿瘤抗原的自身免疫反应引起的。本文总结了副肿瘤性疾病患者的临床特征、可能的自身免疫病理生理机制及管理问题。
