Department of Psychiatry, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Department of Neurology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Cells. 2023 Feb 23;12(5):710. doi: 10.3390/cells12050710.
In modern clinical practice and research on behavioral changes in patients with oncological problems, there are several one-sided approaches to these problems. Strategies for early detection of behavioral changes are considered, but they must take into account the specifics of the localization and phase in the course and treatment of somatic oncological disease. Behavioral changes, in particular, may correlate with systemic proinflammatory changes. In the up-to-date literature, there are a lot of useful pointers on the relationship between carcinoma and inflammation and between depression and inflammation. This review is intended to provide an overview of these similar underlying inflammatory disturbances in both oncological disease and depression. The specificities of acute and chronic inflammation are considered as a basis for causal current and future therapies. Modern therapeutic oncology protocols may also cause transient behavioral changes, so assessment of the quality, quantity, and duration of behavioral symptoms is necessary to prescribe adequate therapy. Conversely, antidepressant properties could be used to ameliorate inflammation. We will attempt to provide some impetus and present some unconventional potential treatment targets related to inflammation. It is certain that only an integrative oncology approach is justifiable in modern patient treatment.
在现代临床实践和对肿瘤患者行为变化的研究中，针对这些问题存在一些片面的方法。已经考虑了早期检测行为变化的策略，但必须考虑到躯体肿瘤疾病的定位和阶段的特殊性以及治疗的特殊性。行为变化，特别是可能与全身炎症性变化相关。在最新的文献中，有很多关于癌症与炎症之间以及抑郁与炎症之间关系的有用提示。本综述旨在概述肿瘤疾病和抑郁中这些相似的潜在炎症紊乱。考虑到急性和慢性炎症的特殊性，它们可作为当前和未来因果治疗的基础。现代肿瘤治疗方案也可能导致短暂的行为变化，因此有必要评估行为症状的质量、数量和持续时间，以开出适当的治疗方案。相反，抗抑郁特性可用于改善炎症。我们将尝试提供一些动力，并提出一些与炎症相关的非传统潜在治疗靶点。可以肯定的是，只有综合肿瘤学方法在现代患者治疗中才是合理的。
