He Yao, Lam Tai Hing, Li Lan Sun, Li Liang Shou, He Shu Fang, Liang Bao Qing
Institute of Geriatrics, Chinese PLA General Hospital, Beijing, China.
Ann Epidemiol. 2004 Jan;14(1):1-7. doi: 10.1016/s1047-2797(03)00069-3.
To study whether serum triglyceride (TG) was associated with coronary heart disease (CHD) mortality.
A cohort analytic study carried out in a machinery factory in Xi'an, China on 1696 subjects aged 35 years or above (1124 men and 572 women) examined in 1976 and followed up till 2000.
At baseline, the mean serum total cholesterol (TC) and triglyceride (TG) was 4.64 and 1.16 mmol/L in men, 4.62 and 1.10 mmol/L in women, respectively. Three hundred six (239 men, 67 women) had died within 37,781 person-years of follow-up, with 49 CHD deaths (36 male, 13 female). The relative risk (95% confidence interval) of CHD mortality per mmol/L increase in TG was 2.13 (1.46-3.17) after adjusting for age, marital status, occupation, education, systolic blood pressure and TC. Dose-response relationship between TG levels by tertiles and CHD risk was found. Stratified analyses showed TG was an independent predictor for CHD mortality in subjects with lower or higher TC.
Chinese had lower levels of TC and TG than Western populations. This study provides new evidence that TG is an independent risk factor of CHD in subjects with lower or higher TC levels, and supports the lowering of cut-off value for elevated triglyceride.
研究血清甘油三酯（TG）是否与冠心病（CHD）死亡率相关。
在中国西安的一家机械厂对1696名35岁及以上的受试者（1124名男性和572名女性）进行队列分析研究，这些受试者于1976年接受检查，并随访至2000年。
基线时，男性血清总胆固醇（TC）和甘油三酯（TG）的均值分别为4.64和1.16 mmol/L，女性分别为4.62和1.10 mmol/L。在37781人年的随访期内，有306人（239名男性，67名女性）死亡，其中49例为冠心病死亡（36例男性，13例女性）。在调整年龄、婚姻状况、职业、教育程度、收缩压和TC后，TG每增加1 mmol/L，冠心病死亡的相对风险（95%置信区间）为2.13（1.46 - 3.17）。发现按三分位数划分的TG水平与冠心病风险之间存在剂量反应关系。分层分析表明，TG是TC水平较低或较高的受试者冠心病死亡的独立预测因素。
中国人的TC和TG水平低于西方人群。本研究提供了新的证据，表明TG是TC水平较低或较高的受试者冠心病的独立危险因素，并支持降低甘油三酯升高的临界值。
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