Lundeberg T C, Eriksson S V, Malm M
Department of Physiology, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden.
Ann Plast Surg. 1992 Oct;29(4):328-31. doi: 10.1097/00000637-199210000-00009.
A controlled study of the effects of electrical nerve stimulation (ENS) was performed in conjunction with a standard treatment for healing chronic diabetic ulcers on 64 patients divided randomly into two groups. All patients received standard treatment (paste-impregnated bandage and a self-adhesive elastic bandage) plus placebo ENS or ENS (alternating constant current; frequency, 80 Hz; pulse width, 1 msec; intensity-evoking strong paresthesias) for 20 minutes twice daily for 12 weeks. Comparison of percentages of healed ulcer area and the number of healed ulcers was made after 2, 4, 6, 8, and 12 weeks. There were significant differences (p < 0.05) in both ulcer area and healed ulcers in the ENS group compared with the placebo group after 12 weeks of treatment. The results of the present study support the use of ENS in diabetic ulcers. ENS is easy to apply and can be used by the patient at home following instructions from a medical doctor or a therapist experienced in electrical stimulation and the treatment of ulcers. Additional studies are needed to identify the mechanisms involved in the promotion of ulcer healing with electrical stimulation and to determine the stimulus variables that most efficaciously accelerate tissue repair.
对64例患者进行了一项关于电神经刺激（ENS）效果的对照研究，这些患者被随机分为两组，该研究与治疗慢性糖尿病溃疡的标准疗法联合进行。所有患者均接受标准治疗（浸膏绷带和自粘弹性绷带）加安慰剂电神经刺激或电神经刺激（交变恒流；频率80赫兹；脉冲宽度1毫秒；引起强烈感觉异常的强度），每天两次，每次20分钟，持续12周。在2周、4周、6周、8周和12周后比较溃疡愈合面积百分比和愈合溃疡数量。治疗12周后，与安慰剂组相比，电神经刺激组的溃疡面积和愈合溃疡数量均有显著差异（p<0.05）。本研究结果支持在糖尿病溃疡中使用电神经刺激。电神经刺激易于应用，患者可在医生或有电刺激及溃疡治疗经验的治疗师指导下在家中使用。需要进一步研究以确定电刺激促进溃疡愈合所涉及的机制，并确定最有效地加速组织修复的刺激变量。
