School of Health Sciences, University of Brighton, Eastbourne, UK.
University of Brighton - Centre for Regenerative Medicine and Devices, Eastbourne, UK.
Int Wound J. 2022 Nov;19(7):1911-1933. doi: 10.1111/iwj.13762. Epub 2022 Feb 2.
Diabetic foot ulcer (DFU) is a life-threatening condition affecting a third of diabetic patients. Many adjuvant therapies aimed at improving the healing rate (HR) and accelerating healing time are currently under investigation. Electrical stimulation (ES) is a physical-based therapy able to increase cells activity and migration into wound bed as well as inhibiting bacterial activity. The aim of this paper was to collect and analyse findings on the effects of ES used in combination with standard wound care (SWC) in the treatment of diabetic foot ulceration compared with SWC alone. A systematic review was performed to synthesise data from quantitative studies from eight databases. Article quality was assessed using the Crowe critical appraisal tool. Seven articles out of 560 publications met the inclusion criteria. A meta-analysis was not performed due to the heterogeneity of the studies and the results were narratively synthetised. Findings showed that HR appears to be higher among diabetic ulcers treated with ES; however, the reliability of these findings is affected by the small sample sizes of the studies. Furthermore, four studies are considered as moderate or high risk of bias. The evidence to suggest the systematic usage of ES in the treatment of DFUs is still insufficient.
糖尿病足溃疡（DFU）是一种危及生命的疾病，影响了三分之一的糖尿病患者。目前有许多旨在提高愈合率（HR）和加速愈合时间的辅助治疗方法正在研究中。电刺激（ES）是一种基于物理的治疗方法，能够增加细胞活性和向创面迁移，并抑制细菌活性。本文的目的是收集和分析 ES 联合标准创面护理（SWC）治疗糖尿病足溃疡与单独使用 SWC 的效果。系统评价从八个数据库中的定量研究中综合数据。使用 Crowe 批判性评估工具评估文章质量。在 560 篇出版物中，有 7 篇符合纳入标准。由于研究的异质性，未进行荟萃分析，结果以叙述性方式综合。结果表明，接受 ES 治疗的糖尿病溃疡的 HR 似乎更高；然而，这些发现的可靠性受到研究样本量小的影响。此外，有四项研究被认为存在中度或高度偏倚风险。目前，仍缺乏系统使用 ES 治疗 DFU 的证据。
