Marguerie C, Lunardi C, So A
Dept of Medicine, Royal Postgraduate Medical School, London, UK.
Immunol Today. 1992 Sep;13(9):336-8. doi: 10.1016/0167-5699(92)90166-5.
Characterization of T cells at sites of autoimmune damage has been difficult. Now, however, polymerase chain reaction (PCR)-based methods are being used to analyse T-cell receptor (TCR) gene expression in such lesions. Here, Christopher Marguerie, Claudio Lunardi and Alex So summarize and interpret the most recent findings and describe the current understanding of TCR usage in autoimmune diseases.
对自身免疫损伤部位的T细胞进行特征描述一直颇具难度。然而现在，基于聚合酶链反应（PCR）的方法正被用于分析此类病变中T细胞受体（TCR）基因的表达。在此，克里斯托弗·马盖里、克劳迪奥·卢纳尔迪和亚历克斯·索总结并解读了最新研究发现，并阐述了目前对自身免疫性疾病中TCR使用情况的理解。
