Matthews R, Burnie J
Department of Medical Microbiology, Manchester University Medical School, UK.
Immunol Today. 1992 Sep;13(9):345-8. doi: 10.1016/0167-5699(92)90169-8.
The immunodominant antigens of many microbial pathogens are heat shock proteins (hsps). In systemic candidal infections, a major target of protective antibody is an epitope shared with human hsp90. Here, Ruth Matthews and James Burnie suggest that fungal hsp90 plays a key pathogenic role in systemic infection by either binding to certain serum proteins, causing them to malfunction, or by mimicking the functional activity of other proteins.
