Harrison L C
Burnet Clinical Research Unit, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Immunol Today. 1992 Sep;13(9):348-52. doi: 10.1016/0167-5699(92)90170-C.
A major goal of research into IDDM has been the identification of the 'causative antigen'. As described in this article by Len Harrison, this reductionist aim is confounded by the fact that numerous candidate islet cell antigens have been described. He scrutinizes the credentials of these candidates and discusses the problem of using autoantibodies to identify causative antigens in a T-cell-mediated disease.
对胰岛素依赖型糖尿病（IDDM）研究的一个主要目标是识别“致病抗原”。正如伦·哈里森在本文中所描述的，这种还原论的目标因已描述了众多候选胰岛细胞抗原这一事实而变得复杂。他仔细审查了这些候选抗原的资质，并讨论了在T细胞介导的疾病中使用自身抗体来识别致病抗原的问题。
