Horel J A
Department of Anatomy and Cell Biology, SUNY, Health Service Center, Syracuse 13210.
Behav Brain Res. 1992 Nov 15;51(2):193-201. doi: 10.1016/s0166-4328(05)80213-x.
While local cooling of inferotemporal cortex (IT) impairs new visual learning, it has little effect on recall. However, in visual discriminations, there is typically extensive exposure to the stimuli before cortical inactivation. Perhaps if recall was prevented before suppression, it would fail during suppression. Three animals with cryodes covering a major part of IT were trained on two face discriminations. They were then run on one of these discriminations for 3 days to create the expectation that the task would be continued with the same stimuli, and on the 4th day, they were started with these stimuli, but after cold suppression, they were switched to a discrimination that they should not have anticipated. IT suppression prevented recall of the discrimination that had not been pre-exposed; performance dropped to chance and stayed there for 50 trials. When they were switched back to the initial pair, performance returned nearly to normal. The experiment was repeated with the role of anticipated and unanticipated stimuli reversed. It was suggested that pre-exposure to the discrimination created the expectation that the same stimuli would continue to be used, and induced information about them to be copied from IT into prestriate cortex.
虽然颞下回皮质（IT）的局部冷却会损害新的视觉学习，但对回忆影响不大。然而，在视觉辨别任务中，通常在皮质失活之前会让动物大量接触刺激物。或许如果在抑制之前阻止回忆，那么在抑制过程中回忆就会失败。对三只颞下回大部分区域被冷冻装置覆盖的动物进行了两项面部辨别训练。然后让它们在其中一项辨别任务上进行3天训练，使其预期任务会继续使用相同的刺激物，在第4天，它们从这些刺激物开始，但在冷抑制后，将它们切换到一个它们不应预期的辨别任务。IT抑制阻止了对未预先接触过的辨别的回忆；表现降至随机水平，并在50次试验中一直保持。当它们切换回最初的一对刺激物时，表现几乎恢复正常。将预期和未预期刺激物的角色颠倒后重复了该实验。研究表明，预先接触辨别任务会产生相同刺激物将继续被使用的预期，并促使关于这些刺激物的信息从IT复制到纹前皮质。
