甲状腺自身免疫

Thyroid autoimmunity.

作者信息

Champion B R, Cooke A, Rayner D C

机构信息

Department of Immunology, Glaxo Inc., Research Triangle Park, North Carolina 27709.

出版信息

Curr Opin Immunol. 1992 Dec;4(6):770-8. doi: 10.1016/0952-7915(92)90060-r.

DOI:10.1016/0952-7915(92)90060-r

PMID:1466801

Abstract

Antigenic structure remains a major focus in thyroid immunology. The genes for three major thyroid antigens--thyroglobulin, thyroid peroxidase and the thyrotropin receptor--were sequenced in the late 1980's, and epitopes for antibody and T cells have been reported within the last year. In addition, new evidence for selective use of T-cell receptor V gene segments in human thyroid infiltrates may point the way to specific immunotherapy.

摘要

抗原结构仍然是甲状腺免疫学的主要研究重点。三种主要甲状腺抗原——甲状腺球蛋白、甲状腺过氧化物酶和促甲状腺激素受体——的基因在20世纪80年代末被测序，并且在过去一年里已经报道了抗体和T细胞的表位。此外，人类甲状腺浸润中T细胞受体V基因片段选择性使用的新证据可能为特异性免疫疗法指明方向。