Sembrowich W L, Knudson M B, Gollnick P D
J Appl Physiol Respir Environ Exerc Physiol. 1977 Dec;43(6):936-41. doi: 10.1152/jappl.1977.43.6.936.
The effect of 18 wk of treadmill running on skeletal muscle metabolism and myocardial function of normal and myopathic hamsters was examined. BIO 14.6 hamsters could tolerate an exercise intensity of about 18 m/min for 40 min, 5 days/wk. Further increases in speed or number of bouts per day resulted in a falloff in performance. Normal hamsters could tolerate higher speeds and longer exercise bouts. Exercise did not change the severity of lesions of either the heart or skeletal muscle of the myopathic hamsters. A training effect was evidenced by increased succinate dehydrogenase activity in the soleus muscle. Cardiac function was evaluated as contractility measured from left ventricular pressure curves and expressed as (dP/dt)/kP. The results suggested that cardiac contractility was not as severely depressed in the trained BIO 14.6 strain of hamsters as in nontrained controls. However, (dP/dt)/kP was lower in the trained myopathic animals than in normal hamsters. ATP, CP, and glycogen levels were lower in myopathic hamsters with the lowest values occurring in the trained group. These data demonstrate that the BIO 14.6 strain of hamster can tolerate exercise training and that such training may have a positive effect on cardiac function.
研究了18周跑步机跑步对正常和患肌病仓鼠骨骼肌代谢及心肌功能的影响。BIO 14.6仓鼠能够耐受约18米/分钟的运动强度，持续40分钟，每周5天。进一步提高速度或每天的运动次数会导致运动表现下降。正常仓鼠能够耐受更高的速度和更长时间的运动。运动并未改变患肌病仓鼠心脏或骨骼肌病变的严重程度。比目鱼肌中琥珀酸脱氢酶活性增加证明了训练效果。通过从左心室压力曲线测量收缩性并表示为(dP/dt)/kP来评估心脏功能。结果表明，经过训练的BIO 14.6品系仓鼠的心脏收缩性不像未训练的对照组那样严重受损。然而，经过训练的患肌病动物的(dP/dt)/kP低于正常仓鼠。患肌病仓鼠的ATP、CP和糖原水平较低，最低值出现在训练组。这些数据表明，BIO 14.6品系仓鼠能够耐受运动训练，并且这种训练可能对心脏功能有积极影响。
