运动对Bio 14.6心肌病仓鼠血流动力学影响的比较。

Comparison of exercise effects on the hemodynamics of the Bio 14.6 cardiomyopathic hamster.

Awad S S, Welty J D, al-Muhailan A R

Department of Physiology Faculty of Medicine, Kuwait University, Safat.

Comp Biochem Physiol A Comp Physiol. 1991;98(2):175-8. doi: 10.1016/0300-9629(91)90515-e.

Abstract

Comparisons of the effects of 4 and 16 weeks of exercise were made on; cardiac output, stroke volume, heart rate, left intraventricular systolic and diastolic pressures, dP/dt, and heart calcium in the Bio 14.6 cardiomyopathic and F1 B hamsters. 2. In the cardiomyopathic hamster the cardiac output, stroke volume, left intraventricular systolic pressure and dP/dt, which were all depressed in the age related sedentary animals, were increased by both periods of exercise. The left intraventricular diastolic pressure which was elevated was likewise decreased by both exercise periods. Only the 16 week exercise period decreased the resting heart rate. 3. In the normal F1 B hamster, both periods of exercise increased the cardiac output and stroke volume while the left intraventricular systolic pressure was decreased. Only the 16 week exercise decreased the resting heart rate and left intraventricular diastolic pressure and increased the left ventricular dP/dt. 4. Both periods of exercise increased the total heart calcium in the Bio 14.6 hamster while the heart calcium in the F1 B was increased only by the 16 week exercise period.

摘要

对患有生物14.6型心肌病的仓鼠和F1 B仓鼠进行了4周和16周运动效果的比较，涉及心输出量、每搏输出量、心率、左心室内收缩压和舒张压、dp/dt以及心脏钙含量。2. 在患有心肌病的仓鼠中，与年龄相关的久坐不动的动物的心输出量、每搏输出量、左心室内收缩压和dp/dt均降低，而这两个运动阶段均使其增加。升高的左心室内舒张压同样在两个运动阶段均降低。只有16周的运动阶段降低了静息心率。3. 在正常的F1 B仓鼠中，两个运动阶段均增加了心输出量和每搏输出量，而左心室内收缩压降低。只有16周的运动降低了静息心率和左心室内舒张压，并增加了左心室dp/dt。4. 两个运动阶段均增加了生物14.6仓鼠的心脏总钙含量，而F1 B仓鼠的心脏钙含量仅在16周运动阶段增加。