Cade W Todd, Fantry Lori E, Nabar Sharmila R, Shaw Donald K, Keyser Randall E
Department of Physical Therapy, University of Maryland School of Medicine, Baltimore, MD, USA.
Arch Phys Med Rehabil. 2003 Dec;84(12):1831-8. doi: 10.1016/j.apmr.2003.03.004.
To determine the effects of human immunodeficiency virus (HIV) and highly active antiretroviral therapy (HAART) on oxygen on-kinetics in HIV-positive persons.
Quasi-experimental cross-sectional.
Infectious disease clinic and exercise laboratory.
Referred participants (N=39) included 13 HIV-positive participants taking HAART, 13 HIV-positive participants not taking HAART, and 13 noninfected controls.
Participants performed 1 submaximal exercise treadmill test below the ventilatory threshold, 1 above the ventilatory threshold, and 1 maximal treadmill exercise test to exhaustion.
Change in oxygen consumption (Delta.VO2) and oxidative response index (Delta.VO2/mean response time).
Delta.VO2 was significantly lower in both HIV-positive participants taking (946.5+/-68.1mL) and not taking (871.6+/-119.6mL) HAART than in controls (1265.3+/-99.8mL) during submaximal exercise above the ventilatory threshold. The oxidative response index was also significantly lower (P<.05) in HIV-positive participants both taking (15.0+/-1.3mL/s) and not taking (15.1+/-1.7mL/s) HAART than in controls (20.8+/-2.1mL/s) during exercise above the ventilatory threshold.
Oxygen on-kinetics during submaximal exercise above the ventilatory threshold was impaired in HIV-positive participants compared with a control group, and it appeared that the attenuated oxygen on-kinetic response was primarily caused by HIV infection rather than HAART.
