Exploratory study on oxygen consumption on-kinetics during treadmill walking in women with systemic lupus erythematosus.

OBJECTIVE

To determine whether oxygen consumption (V o(2)) on-kinetics differed between groups of women with systemic lupus erythematosus (SLE) and sedentary but otherwise healthy controls.

DESIGN

Exploratory case-control study.

SETTING

Medical school exercise physiology laboratory.

PARTICIPANTS

Convenience samples of women with SLE (n=12) and sedentary but otherwise healthy controls (n=10).

INTERVENTION

None.

MAIN OUTCOME MEASURES

V o(2) on-kinetics indices including time to steady state, rate constant, mean response time (MRT), transition constant, and oxygen deficit measured during bouts of treadmill walking at intensities of 3 and 5 metabolic equivalents (METs).

RESULTS

Time to steady state and oxygen deficit were increased and rate constant was decreased in the women with SLE compared with controls. At the 5-MET energy demand, the transition constant was lower and MRT was longer in the women with SLE than in controls. For a similar relative energy expenditure that was slightly lower than the anaerobic threshold, the transition constant was higher in controls than in women with SLE.

CONCLUSION

V o(2) on-kinetics was prolonged in women with SLE. The prolongation was concomitant with an increase in oxygen deficit and may underlie performance fatigability in women with SLE.