Kandpal N, Shukla G K, Bhatia N, Agarwal S P, Saha S, Puri V N
Department of Otorhinolaryngology, King George Medical College, Lucknow, U.P., India.
J Laryngol Otol. 2003 Nov;117(11):871-4. doi: 10.1258/002221503322542872.
In this study the status of oxidant stress, vitamin A and angiotensin-converting enzyme (ACE) levels were evaluated in cases of laryngeal carcinoma patients from Northern India. In control subjects the levels of malondialdehyde (MDA), vitamin A and ACE were 0.23 +/- 0.07 nmole/ml, 2515 +/- 84 IU, and 1.4 +/- 0.8 U/ml respectively. Thirty laryngeal cancer patients were divided into three groups according to the TNM classification (American Joint Committee on Cancers). In laryngeal cancer patients according to tumour size, MDA and ACE levels increased to 0.32 +/- 0.04 nmole/ml and 4.7 +/- 0.5 U/ml respectively and the effect was statistically significant (p<0.01). The correlation coefficient between different subgroups was also highly significant (r=0.96, p<0.01). However, serum vitamin A levels decreased to 621 +/- 20 IU and the effect was statistically significant (p<0.01). In another two groups of laryngeal cancer patients, a similar pattern of various markers was obtained. Thirty patients with laryngeal carcinoma were divided into four different groups according to nodal involvement and it was observed that in laryngeal cancer patients with no nodal involvement, ACE levels were low 3.6 +/- 1.4 U/ml while patients with maximum nodal involvement had the highest levels of ACE 7.1 +/- 0.18 U/ml. The correlation coefficient between different groups is highly statistically significant (r=0.95, p<0.01). In patients with laryngeal cancer the serum MDA and vitamin A levels correlation coefficient between different groups was not significant. It is thus concluded that serum ACE might be a specific test marker for laryngeal cancer disease burden. The use of this marker enzyme for therapeutics is being planned.
在本研究中，对来自印度北部的喉癌患者的氧化应激状态、维生素A和血管紧张素转换酶（ACE）水平进行了评估。在对照组中，丙二醛（MDA）、维生素A和ACE的水平分别为0.23±0.07纳摩尔/毫升、2515±84国际单位和1.4±0.8单位/毫升。30例喉癌患者根据TNM分类（美国癌症联合委员会）分为三组。根据肿瘤大小，喉癌患者的MDA和ACE水平分别升至0.32±0.04纳摩尔/毫升和4.7±0.5单位/毫升，且差异具有统计学意义（p<0.01）。不同亚组之间的相关系数也非常显著（r=0.96，p<0.01）。然而，血清维生素A水平降至621±20国际单位，差异具有统计学意义（p<0.01）。在另外两组喉癌患者中，也获得了类似的各种标志物模式。30例喉癌患者根据淋巴结受累情况分为四个不同组，观察到无淋巴结受累的喉癌患者ACE水平较低，为3.6±1.4单位/毫升，而淋巴结受累最多的患者ACE水平最高，为7.1±0.18单位/毫升。不同组之间的相关系数具有高度统计学意义（r=0.95，p<0.01）。在喉癌患者中，不同组之间血清MDA和维生素A水平的相关系数不显著。因此得出结论，血清ACE可能是喉癌疾病负担的一种特异性检测标志物。目前正在计划将这种标志物酶用于治疗。
