Kapil U, Singh P, Bahadur S, Shukla N K, Dwivedi S, Pathak P, Singh R
Department of Human Nutrition, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110 029. India.
Indian J Cancer. 2003 Apr-Jun;40(2):67-70.
The incidence of the cancers of the oral cavity, pharynx, esophagus and larynx in different population groups of India is amongst the highest reported in Asian countries. There is evidence that high dietary carotenoids and vitamin C may possibly decrease the risk of laryngeal cancer. Limited data is available from India on the association between these micronutrients and the risk of laryngeal cancer.
To assess the levels of vitamin A, vitamin C and zinc in laryngeal cancer patients and healthy controls.
A hospital based case- control study.
One hundred and fifty five laryngeal cancer patients and a control group of 155 healthy individuals constituted the study population. Individuals in the control group were individually matched with the patients for their age +/- 2 years, sex and place of residence. Venous blood was drawn from the cases and controls and estimations of vitamin A, zinc and vitamin C was done utilizing the standard procedures.
Paired 't' test to compare the mean serum levels of vitamin A and zinc and plasma vitamin C between laryngeal cancer patients and controls. Univariate logistic regression analysis to calculate the odds ratios and the confidence intervals.
The mean serum vitamin A, zinc and plasma vitamin C levels were significantly lower in laryngeal cancer patients as compared to the controls.
The findings of the present study indicated a strong association of these micronutrients with laryngeal cancer in the Indian population.
在印度不同人群中，口腔癌、咽癌、食管癌和喉癌的发病率位居亚洲国家报道的最高水平之列。有证据表明，高膳食类胡萝卜素和维生素C可能会降低喉癌风险。印度关于这些微量营养素与喉癌风险之间关联的数据有限。
评估喉癌患者和健康对照者体内维生素A、维生素C和锌的水平。
一项基于医院的病例对照研究。
155例喉癌患者和155名健康个体组成的对照组构成研究人群。对照组个体在年龄（±2岁）、性别和居住地点方面与患者进行个体匹配。从病例组和对照组抽取静脉血，采用标准程序测定维生素A、锌和维生素C。
采用配对“t”检验比较喉癌患者与对照组之间维生素A和锌的平均血清水平以及血浆维生素C水平。采用单因素逻辑回归分析计算比值比和置信区间。
与对照组相比，喉癌患者的血清维生素A、锌和血浆维生素C平均水平显著较低。
本研究结果表明，在印度人群中，这些微量营养素与喉癌之间存在密切关联。
