晚期喉癌患者血浆中丙二醛和一氧化氮水平
Malondialdehyde and nitric oxide levels in the plasma of patients with advanced laryngeal cancer.
作者信息
Taysi Seyithan, Uslu Celil, Akcay Fatih, Sutbeyaz Mehmet Yavuz
机构信息
Department of Biochemistry, School of Medicine, Atatürk University, Medical School, 25240 Erzurum, Turkey.
出版信息
Surg Today. 2003;33(9):651-4. doi: 10.1007/s00595-002-2562-3.
PURPOSE
We investigated alterations in plasma nitrite, nitrate, total nitric oxide (NO*), and malondialdehyde (MDA) levels in patients with advanced stage laryngeal cancer.
METHODS
We measured the levels of MDA and total NO2-, as well as the NO3- marker for NO* generation, in 25 patients with advanced laryngeal cancer and 15 healthy control subjects.
RESULTS
The levels of plasma MDA, NO*, and NO3- were significantly higher in the patients with laryngeal cancer than in the healthy controls (P < 0.001 for all). On the other hand, although plasma NO2- was increased in the patient group, the statistical difference was not significant (P > 0.05). Moreover, the MDA and NO* levels did not differ significantly between patients with stage III and stage IV laryngeal cancer.
CONCLUSION
These findings demonstrate that oxidative stress is increased in patients with advanced laryngeal cancer.
目的
我们研究了晚期喉癌患者血浆中亚硝酸盐、硝酸盐、总一氧化氮（NO*）和丙二醛（MDA）水平的变化。
方法
我们测量了25例晚期喉癌患者和15名健康对照者的MDA水平、总NO2-水平以及作为NO*生成标志物的NO3-水平。
结果
喉癌患者血浆MDA、NO和NO3-水平显著高于健康对照组（所有P<0.001）。另一方面，虽然患者组血浆NO2-有所升高，但统计学差异不显著（P>0.05）。此外，III期和IV期喉癌患者的MDA和NO水平无显著差异。
结论
这些发现表明晚期喉癌患者的氧化应激增加。
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