Taysi Seyithan, Uslu Celil, Akcay Fatih, Sutbeyaz Mehmet Yavuz
Department of Biochemistry, School of Medicine, Atatürk University, Medical School, 25240 Erzurum, Turkey.
Surg Today. 2003;33(9):651-4. doi: 10.1007/s00595-002-2562-3.
We investigated alterations in plasma nitrite, nitrate, total nitric oxide (NO*), and malondialdehyde (MDA) levels in patients with advanced stage laryngeal cancer.
We measured the levels of MDA and total NO2-, as well as the NO3- marker for NO* generation, in 25 patients with advanced laryngeal cancer and 15 healthy control subjects.
The levels of plasma MDA, NO*, and NO3- were significantly higher in the patients with laryngeal cancer than in the healthy controls (P < 0.001 for all). On the other hand, although plasma NO2- was increased in the patient group, the statistical difference was not significant (P > 0.05). Moreover, the MDA and NO* levels did not differ significantly between patients with stage III and stage IV laryngeal cancer.
These findings demonstrate that oxidative stress is increased in patients with advanced laryngeal cancer.
我们研究了晚期喉癌患者血浆中亚硝酸盐、硝酸盐、总一氧化氮（NO*）和丙二醛（MDA）水平的变化。
我们测量了25例晚期喉癌患者和15名健康对照者的MDA水平、总NO2-水平以及作为NO*生成标志物的NO3-水平。
喉癌患者血浆MDA、NO和NO3-水平显著高于健康对照组（所有P<0.001）。另一方面，虽然患者组血浆NO2-有所升高，但统计学差异不显著（P>0.05）。此外，III期和IV期喉癌患者的MDA和NO水平无显著差异。
这些发现表明晚期喉癌患者的氧化应激增加。
