Oshtrakh M I
Division of Applied Biophysics, Faculty of Physical Techniques and Devices for Quality Control, Ural State Technical University, Ekaterinburg 620002, Russian Federation.
Spectrochim Acta A Mol Biomol Spectrosc. 2004 Jan;60(1-2):217-34. doi: 10.1016/s1386-1425(03)00209-9.
This review considers the results of experimental Mössbauer studies and theoretical calculations of the effect of small variations of protein molecular structure on the iron electronic structure and stereochemistry in order to understand the proteins structural heterogeneity and functional variety. Structural changes in iron containing proteins during various diseases are also considered. These results show the relationship of the small structural variations and Mössbauer parameters of iron containing proteins and demonstrate the possibilities of Mössbauer spectroscopy to obtain new information at the molecular level in biomedical research.
本综述探讨了实验性穆斯堡尔研究的结果以及蛋白质分子结构的微小变化对铁电子结构和立体化学影响的理论计算，以了解蛋白质的结构异质性和功能多样性。还考虑了含铁蛋白质在各种疾病过程中的结构变化。这些结果表明了含铁蛋白质的微小结构变化与穆斯堡尔参数之间的关系，并证明了穆斯堡尔光谱在生物医学研究中获取分子水平新信息的可能性。
