人肝和胎盘微粒体对7-烷氧基喹啉的O-脱烷基作用。
7-Alkoxyquinoline O-dealkylation by microsomes from human liver and placenta.
作者信息
Hakkola J, Mäenpää J, Mayer R T, Park S S, Gelboin H V, Pelkonen O
机构信息
Department of Pharmacology and Toxicology, University of Oulu, Finland.
出版信息
Br J Clin Pharmacol. 1992 Nov;34(5):415-20. doi: 10.1111/j.1365-2125.1992.tb05650.x.
Abstract
- The O-dealkylation of seven 7-alkoxyquinoline derivatives by human hepatic and placental microsomes and the effect of maternal cigarette smoking on placental 7-alkoxyquinoline metabolism was studied. 2. None of several monoclonal antibodies to isoenzymes of cytochrome P450 had a clear effect on metabolism of the compounds by liver microsomes. 3. Maternal cigarette smoking induced the O-dealkylation of all of the 7-alkoxyquinoline derivatives, being greatest for 7-butoxy- and 7-benzyloxyquinoline. 4. Placental 7-alkoxyquinoline metabolism induced by smoking was partially inhibited by the monoclonal antibody 1-7-1 raised against 3-methylcholanthrene-induced rat liver P450. 5. None of the 7-alkoxyquinoline O-dealkylations could be assigned specifically to any known P450 isoenzyme in human liver or placenta.
摘要
- 研究了七种7-烷氧基喹啉衍生物在人肝微粒体和胎盘微粒体中的O-脱烷基化反应，以及孕妇吸烟对胎盘7-烷氧基喹啉代谢的影响。2. 几种针对细胞色素P450同工酶的单克隆抗体对肝微粒体中化合物的代谢均无明显作用。3. 孕妇吸烟可诱导所有7-烷氧基喹啉衍生物的O-脱烷基化反应，其中对7-丁氧基喹啉和7-苄氧基喹啉的诱导作用最强。4. 针对3-甲基胆蒽诱导的大鼠肝P450产生的单克隆抗体1-7-1可部分抑制吸烟诱导的胎盘7-烷氧基喹啉代谢。5. 7-烷氧基喹啉的O-脱烷基化反应无法明确归属于人肝或胎盘中任何已知的P450同工酶。
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