Weissberg N, Schwartz G, Shemesh O, Brooks B A, Algur N, Eylath U, Abraham A S
Department of Internal Medicine B, Shaare Zedek Medical Centre, Jerusalem, Israel.
Magnes Res. 1992 Sep;5(3):173-7.
Thirty women in their third trimester of pregnancy (37-42 weeks), 40 women during and 72 h after labour and 18 non-pregnant controls were studied for changes in serum and mononuclear cell cation content, and their relationship to cervical effacement and intensity of pain as measured by plasma beta endorphin concentrations during labour. Serum magnesium fell from 0.95 +/- 0.01 (mean +/- SEM) to 0.84 +/- 0.02 mmol/litre at late pregnancy and further to 0.76 +/- 0.01 during labour (P < 0.001); serum potassium fell from 4.25 +/- 0.05 to 3.79 +/- 0.06 mmol/litre (P < 0.0001) during labour; and serum calcium fell from 2.40 +/- 0.02 to 2.28 +/- 0.01 mmol/litre at late pregnancy (P < 0.001) and further to 2.25 +/- 0.02 mmol/litre during labour (P < 0.001). Mononuclear cell magnesium content rose from 4.5 +/- 0.3 to 5.6 +/- 0.04 fmol/cell (P < 0.02); potassium content rose from 37.7 +/- 2.0 to 50.9 +/- 3.0 fmol/cell (P < 0.001); and calcium content rose from 4.4 +/- 0.4 to 7.6 +/- 1.1 fmol/cell (P < 0.105). On the other hand, mononuclear cell sodium content fell from 7.2 +/- 0.5 to 3.8 +/- 0.3 fmol/cell (P < 0.001). Plasma beta endorphin concentrations increased with increasing degrees of effacement, as did intracellular Na, whereas intracellular Mg and K showed an inverse trend. A significant correlation was found between intracellular cation and beta endorphin levels (r = -0.98, Mg; -0.99, K; 0.83, Na). These changes are probably due either to intercompartmental cation shifts or possibly to endometrial ischaemia and damage during labour.
研究了30名妊娠晚期（37 - 42周）的女性、40名分娩期间及分娩后72小时的女性以及18名非妊娠对照者血清和单核细胞阳离子含量的变化，及其与宫颈消退和分娩时血浆β - 内啡肽浓度所测疼痛强度的关系。妊娠晚期血清镁从0.95±0.01（均值±标准误）降至0.84±0.02 mmol/升，分娩时进一步降至0.76±0.01 mmol/升（P<0.001）；分娩时血清钾从4.25±0.05降至3.79±0.06 mmol/升（P<0.0001）；妊娠晚期血清钙从2.40±0.02降至2.28±0.01 mmol/升（P<0.001），分娩时进一步降至2.25±0.02 mmol/升（P<0.001）。单核细胞镁含量从4.5±0.3升至5.6±0.04 fmol/细胞（P<0.02）；钾含量从37.7±2.0升至50.9±3.0 fmol/细胞（P<0.001）；钙含量从4.4±0.4升至7.6±1.1 fmol/细胞（P<0.105）。另一方面，单核细胞钠含量从7.2±0.5降至3.8±0.3 fmol/细胞（P<0.001）。血浆β - 内啡肽浓度随消退程度增加而升高，细胞内钠也是如此，而细胞内镁和钾则呈相反趋势。细胞内阳离子与β - 内啡肽水平之间存在显著相关性（r = -0.98，镁；-0.99，钾；0.83，钠）。这些变化可能是由于细胞间阳离子转移，也可能是由于分娩时子宫内膜缺血和损伤。
