[老年心血管药物治疗]

[Cardiovascular pharmacotherapy in the aged].

作者信息

Baumhäkel M, Böhm M

机构信息

Innere Medizin III, Medizinische Klinik und Poliklinik, Universitätskliniken des Saarlandes, Homburg.

出版信息

Internist (Berl). 2003 Aug;44(8):943-50. doi: 10.1007/s00108-003-0939-z.

DOI:10.1007/s00108-003-0939-z

PMID:14671808

Abstract

Prevalence of cardiovascular diseases increases with advancing age. Moreover, these patients are getting older and older. Therefore, pharmacotherapy of the elderly becomes a major objective in clinical cardiology. Pharmacodynamic and pharmacokinetic changes in the elderly can interfere with a sufficient treatment of cardiovascular diseases and moreover, multiple drug usage is a considerable risk factor of possible drug-drug interactions. Furthermore, treatment of cardiovascular diseases as hypertension, heart failure or coronary heart disease in the elderly according to the international guidelines is often limited due to co-morbidities restricting usage of the appropriate medication. This review addresses both, the treatment of cardiovascular diseases in the elderly and the pharmacological characteristics of frequently used drugs.

摘要

心血管疾病的患病率随着年龄的增长而增加。此外，这些患者的年龄越来越大。因此，老年患者的药物治疗成为临床心脏病学的一个主要目标。老年人的药效学和药代动力学变化会干扰心血管疾病的充分治疗，而且，多种药物联合使用是可能发生药物相互作用的一个重要危险因素。此外，根据国际指南对老年人的心血管疾病如高血压、心力衰竭或冠心病进行治疗时，由于合并症限制了适当药物的使用，往往受到限制。这篇综述既探讨了老年人心血管疾病的治疗，也探讨了常用药物的药理学特性。