Ito H, Komai T, Yamamoto S
J Neurosurg. 1978 Feb;48(2):197-200. doi: 10.3171/jns.1978.48.2.0197.
Active plasmin, available plasmin, and total plasminogen were measured by Enzo-diffusion fibirn plate techniques in 11 cases and level of tissue activator and tissue fibrinolytic activities in another 11 cases with chronic subdural hematoma. The values were too small to be measured in some instances. Anti-plasmin in the hematoma was less than in the blood plasma. The outer membrane contained about three times more tissue activator than the dura mater, although the inner membrane contained none. Increased tissue activator, which exudes from the extremely vascular outer membrane, transforms plasminogen into plasmin in subdural hematoma, so that plasmin breaks down fibrin and fibrinogen and induces continuous hemorrhage.
采用恩佐扩散纤维蛋白平板技术对11例慢性硬膜下血肿患者测定活性纤溶酶、可用纤溶酶和总纤溶酶原，并对另外11例患者测定组织激活剂水平和组织纤溶活性。在某些情况下，这些值太小无法测量。血肿中的抗纤溶酶低于血浆中的抗纤溶酶。外膜所含组织激活剂比硬脑膜多约三倍，而内膜不含组织激活剂。从血管极其丰富的外膜渗出的组织激活剂增加，在硬膜下血肿中将纤溶酶原转化为纤溶酶，从而使纤溶酶分解纤维蛋白和纤维蛋白原并导致持续出血。
