Gupta Amitabh, Tsai Li-Huei
Department of Pathology, Harvard Medical School and Howard Hughes Medical Institute, Boston, Mass. 02115, USA.
Neurosignals. 2003 Sep-Oct;12(4-5):173-9. doi: 10.1159/000074618.
The cyclin-dependent kinase 5 (Cdk5) plays an important role in the proper establishment of neocortical layers. Over the past several years, key molecular targets of Cdk5 have been identified that show intriguing connections to the adhesional and cytoskeletal components of cell movement. This molecular knowledge about Cdk5 signaling has begun to translate into an understanding of how Cdk5 regulates the cellular physiology of neocortical layer formation. Together with recent progress on the signaling relationship between Cdk5 and Reelin, the other key protein involved in neocortical layer formation, and their relationship to migration modes, research on understanding neocortical layer formation has arrived at a most promising crossroad.
细胞周期蛋白依赖性激酶5（Cdk5）在新皮质层的正常形成过程中发挥着重要作用。在过去几年里，已确定了Cdk5的关键分子靶点，这些靶点显示出与细胞运动的粘附和细胞骨架成分存在有趣的联系。关于Cdk5信号传导的这一分子知识已开始转化为对Cdk5如何调节新皮质层形成的细胞生理学的理解。随着Cdk5与Reelin（参与新皮质层形成的另一种关键蛋白）之间信号关系的最新进展，以及它们与迁移模式的关系，关于理解新皮质层形成的研究已来到了一个最有前景的十字路口。
