Ohshima Toshio, Mikoshiba Katsuhiko
Brain Science Institute, The Institute of Physical and Chemical Research (RIKEN), Wako, Saitama, Japan.
Mol Neurobiol. 2002 Oct-Dec;26(2-3):153-66. doi: 10.1385/MN:26:2-3:153.
Neuronal positioning is important for higher brain function because it is the architectural basis of the formation of precise synaptic circuits. Analysis of neurological mutant mice has led to dramatic progress in the identification and characterization of molecules important for neuronal positioning in the developing mammalian brain. Among these molecules, identification of signal pathways mediated by Reelin and Cdk5 kinase has provided a conceptual framework for exploring the molecular mechanisms underlying proper neuronal positioning in the developing mammalian brain. Recent evidence has implicated synergism between Reelin signaling and Cdk5 in contributing to the proper positioning of selective neuronal populations.
神经元定位对于高等脑功能很重要，因为它是精确突触回路形成的结构基础。对神经突变小鼠的分析已在识别和表征发育中的哺乳动物大脑中对神经元定位重要的分子方面取得了显著进展。在这些分子中，对由Reelin和Cdk5激酶介导的信号通路的识别为探索发育中的哺乳动物大脑中神经元正确定位的分子机制提供了一个概念框架。最近的证据表明，Reelin信号和Cdk5之间的协同作用有助于选择性神经元群体的正确定位。
