Nikolic Margareta
MRC Centre for Developmental Neurobiology, New Hunt's House, King's College London, London SE1 1UL, UK.
Trends Cell Biol. 2004 Jan;14(1):1-5. doi: 10.1016/j.tcb.2003.10.010.
The basic building blocks of a cell are its cytoskeletal proteins, the orderly but dynamic organization of which is essential. How signalling molecules regulate the cytoskeleton in the developing nervous system is still largely unknown. A recent breakthrough sheds light on a pathway involving Cdk5 (cyclin-dependent kinase 5) and FAK (focal adhesion kinase), demonstrating their role in regulating microtubule structure and thus nuclear positioning in radially migrating cortical neurones.
细胞的基本组成部分是其细胞骨架蛋白，这些蛋白有序但动态的组织形式至关重要。信号分子如何在发育中的神经系统中调节细胞骨架，目前仍 largely unknown（此处原文有误，应改为“largely unknown”，意为“很大程度上未知”）。最近的一项突破揭示了一条涉及Cdk5（细胞周期蛋白依赖性激酶5）和FAK（粘着斑激酶）的途径，证明了它们在调节微管结构从而在放射状迁移的皮层神经元中调节细胞核定位方面的作用。
