Carlson Mary L, Wilson Ellen T, Prescott Stephen M
Huntsman Cancer Institute and the Department of Oncological Sciences, University of Utah, USA.
Mol Cancer. 2003 Dec 15;2:42. doi: 10.1186/1476-4598-2-42.
Cyclooxygenase-2 (COX-2) is expressed early in colon carcinogenesis and is known to play a crucial role in the progress of the disease. Here we show that the regulation of the expression of this enzyme in a colon cancer cell line, and in patients, is associated with overexpression of the Wnt pathway-associated proteins, Pontin52/TIP49a and LEF-1. Recently shown to be essential for transformation via the c-Myc pathway, Pontin52/TIP49a promotes COX-2 expression in tissue culture and is overexpressed in colon cancer tissue, co-localizing with COX-2 expression in transformed tissue, relative to paired normal tissue.
环氧化酶-2（COX-2）在结肠癌发生早期即有表达，且已知其在疾病进展中起关键作用。在此我们表明，该酶在结肠癌细胞系及患者中的表达调控与Wnt通路相关蛋白Pontin52/TIP49a和淋巴样增强因子1（LEF-1）的过表达有关。Pontin52/TIP49a最近被证明对通过c-Myc通路进行的转化至关重要，它在组织培养中促进COX-2表达，且在结肠癌组织中过表达，相对于配对的正常组织，其在转化组织中与COX-2表达共定位。
