Lovestone S, Anderton B
Neurodegenerative Diseases Group, Institute of Psychiatry, London, UK.
Curr Opin Neurol Neurosurg. 1992 Dec;5(6):883-8.
A fundamental process in the pathogenesis of Alzheimer's disease (AD) is the breakdown of the cytoskeleton. The microscopic manifestation of this--neurofibrillary tangles--is described. Tangles are formed from paired helical filaments (PHF), in turn constructed from abnormally phosphorylated Tau proteins. Recent investigations on the process of Tau phosphorylation and possible links between amyloid deposition and tangle formation are reviewed.
阿尔茨海默病（AD）发病机制中的一个基本过程是细胞骨架的破坏。文中描述了这一过程的微观表现——神经原纤维缠结。缠结由双螺旋丝（PHF）形成，而双螺旋丝又由异常磷酸化的 Tau 蛋白构成。本文综述了近期关于 Tau 蛋白磷酸化过程以及淀粉样蛋白沉积与缠结形成之间可能联系的研究。
