Bürger S, Meinardus A, Strauer B E
Klin Wochenschr. 1978 Feb 15;56(4):207-9. doi: 10.1007/BF01705384.
Left ventricular dynamics and papillary muscle mechanics were examined in 44 spontaneously hypertensive rats (SHR) (Okamoto, 9-21 weeks old), in 38 normotensive Wistar Kyoto inbred rats and in 31 control rats. In spite of marked pressure overload, SHR had normal peak systolic wall stress and reduced (21%) diastolic wall stress due to an increased proportion between left ventricular wall thickness and radius. Left ventricular function was normal (isovolumic contractility indices before and after aortic clamping) or augmented (pressure development per gramm of left ventricular weight before and after clamping). Papillary muscle mechanics showed decreases of contraction velocities (isometric and isotonic), whereas shortening and maximum tension development were nearly unaffected. Left ventricular hypertrophy in proportion to pressure overload, the increase in wall thickness/radius ratio and hence the normalisation or decrease of wall stress, provides normal left ventricular function even at extreme pressure overload.
对44只自发性高血压大鼠（SHR）（冈本种，9 - 21周龄）、38只血压正常的近交系Wistar Kyoto大鼠以及31只对照大鼠的左心室动力学和乳头肌力学进行了研究。尽管存在明显的压力超负荷，但由于左心室壁厚度与半径之间的比例增加，SHR的收缩期峰值壁应力正常，舒张期壁应力降低（21%）。左心室功能正常（主动脉夹闭前后的等容收缩性指标）或增强（夹闭前后每克左心室重量的压力发展）。乳头肌力学显示收缩速度（等长和等张）降低，而缩短和最大张力发展几乎未受影响。与压力超负荷成比例的左心室肥厚、壁厚/半径比值的增加以及壁应力的正常化或降低，即使在极端压力超负荷情况下也能提供正常的左心室功能。
