Christe M E, Perretta A A, Li P, Capasso J M, Anversa P, Rodgers R L
Department of Pharmacology and Toxicology, University of Rhode Island, Kingston 02881.
Am J Physiol. 1994 Nov;267(5 Pt 2):H2050-7. doi: 10.1152/ajpheart.1994.267.5.H2050.
The purpose of this study was to characterize the effect of chronic treatment with an angiotensin-converting enzyme (ACE) inhibitor on left ventricular function in spontaneously hypertensive rats (SHR). Cilazapril (5 mg/kg) was administered in the drinking water continuously for 11 wk, beginning at 4 wk of age. Systolic arterial pressure (SAP) was monitored weekly. At the end of the 11-wk period, left ventricular function was quantified using the perfused working heart preparation. Cilazapril exerted a rapid, complete, and persistent antihypertensive effect in the SHR in vivo but had no effect on SAP in the normotensive Sprague-Dawley (S-D) group. Nevertheless, the drug reduced left ventricular weight to the same extent in both strains. Function of untreated SHR hearts was not different from that of the untreated S-D hearts. Cilazapril treatment depressed heart performance (28-35%) in SHR but had no effect in the S-D group. The decline in pump performance in SHR hearts was associated with diminished tension development and velocity of shortening of papillary muscles. These results demonstrate that an ACE inhibitor, administered to young SHR, produces a reduction in left ventricular contractile function, which may be due to a decline in muscle contractility and which cannot be explained exclusively by the reduction in left ventricular mass.
本研究的目的是描述用血管紧张素转换酶（ACE）抑制剂长期治疗对自发性高血压大鼠（SHR）左心室功能的影响。从4周龄开始，在饮用水中持续给予西拉普利（5 mg/kg），持续11周。每周监测收缩动脉压（SAP）。在11周结束时，使用灌注工作心脏标本对左心室功能进行定量分析。西拉普利在体内对SHR产生快速、完全且持久的降压作用，但对正常血压的斯普拉格-道利（S-D）组的SAP无影响。然而，该药物在两种品系中均使左心室重量减轻至相同程度。未治疗的SHR心脏功能与未治疗的S-D心脏功能无差异。西拉普利治疗使SHR的心脏功能降低（28%-35%），但对S-D组无影响。SHR心脏泵功能的下降与乳头肌张力发展和缩短速度的降低有关。这些结果表明，给年轻SHR施用ACE抑制剂会导致左心室收缩功能降低，这可能是由于肌肉收缩力下降所致，且不能仅用左心室质量的减少来解释。
