Hartikainen Sirpa, Rahkonen Terhi, Kautiainen Hannu, Sulkava Raimo
Division of Geriatrics, Department of Public Health and General Practice, University of Kuopio, Finland.
Int J Geriatr Psychiatry. 2003 Dec;18(12):1135-41. doi: 10.1002/gps.1024.
To describe the use of psychotropics in the nondemented and demented elderly.
The home-dwelling elderly (n=523) among the random sample of 700 subjects from the total population of individuals aged 75 years or more in 1998 and living in the city of Kuopio, Finland.
A trained nurse interviewed the participants about their health and current use of medicines. A geriatrician performed clinical examinations and diagnosed diseases. Dementia and depression were diagnosed according to the DSM-IV criteria.
The demented subjects used more medicines of all kinds (p<0.01), and especially more psychotropics than the nondemented (p<0.001). One in four demented subjects, compared to one in ten nondemented ones used at least two psychotropics (p<0.01). The demented subjects used antipsychotics six times more often than the nondemented ones (p<0.001). Among the nondemented subjects, one out of two antipsychotics users was suffering from depression according to DSM-IV criteria. Three out of four persons who had dementia with Lewy bodies were using psychotropics. Persons with moderate dementia were more commonly using all kinds of psychotropic preparations especially, antipsychotics three times more commonly than persons with mild or severe dementia.
Psychotropics, especially antipsychotics, are commonly used in the treatment of both nondemented and demented elderly, even without proper indication. Physicians need more training about the appropriate use of psychotropics to minimize their adverse effects.
描述精神药物在非痴呆和痴呆老年人中的使用情况。
1998年从芬兰库奥皮奥市75岁及以上总人口中随机抽取的700名受试者中的居家老年人(n = 523)。
一名经过培训的护士就参与者的健康状况和当前用药情况进行访谈。一名老年病科医生进行临床检查并诊断疾病。根据《精神疾病诊断与统计手册》第四版(DSM-IV)标准诊断痴呆和抑郁症。
痴呆受试者使用的各类药物更多(p < 0.01),尤其是精神药物比非痴呆受试者更多(p < 0.001)。四分之一的痴呆受试者使用至少两种精神药物,而十分之一的非痴呆受试者使用至少两种精神药物(p < 0.01)。痴呆受试者使用抗精神病药物的频率是非痴呆受试者的六倍(p < 0.001)。在非痴呆受试者中,根据DSM-IV标准,每两名使用抗精神病药物的人中就有一人患有抑郁症。四分之三患有路易体痴呆的人正在使用精神药物。中度痴呆患者更常使用各类精神药物制剂,尤其是抗精神病药物,其使用频率是轻度或重度痴呆患者的三倍。
精神药物,尤其是抗精神病药物,常用于治疗非痴呆和痴呆老年人,甚至在没有适当指征的情况下也是如此。医生需要接受更多关于精神药物合理使用的培训,以尽量减少其不良反应。